Toxic Effects of Ribavirin on the Testicular Interstitium in Albino Rats

Introduction: Ribavirin due to its mutagenic property exerts cytotoxic effects on gonads in a transient fashion that have been studied the testicular tissues of various experimental animals. Ample data is not available regarding toxicity interstitium has led this research.
 Aims & Objectives: Aim study was evaluation ribavirin different doses at time points albino rats.
 Place and duration study: The experiment performed Anatomy Department Postgraduate Medical Institute, Lahore completed three months.
 Material Methods: 72 adult male rats were divided into 4 equal groups with 18 every group. 0.75ml distilled water given Control (A) group intraperitoneally administered by same route doses: 20mg, 100mg 200mg/kg body weight, single dose for 5 days B, C D respectively. Every subdivided 3 small subgroups accordance 20th, 40th 60th sacrificial from last drug. On each 6 selected sacrificed. Data entered SPSS 23.0 software comparison among made Pearson’s chi square test. P-value <0.05 considered significant.
 Results: Interstitial widening edema congested vessels observed all 20th day control Signs recovery form decrease widening, congestion only low high didn’t show reversibility these changes.
 Conclusion: A patient who taking as an antiviral therapy should be counselled about gonadotoxicity.